Home > Signal Pathway > Epigenetics > Aurora Kinase

Aurora Kinase


Aurora kinases are serine/threonine kinases that are essential for cell proliferation. The enzyme helps the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis.
There are three classes of aurora kinases:Aurora A (aka, Aurora 2) functions during prophase of mitosis and is required for correct function of the centrosomes (the microtubule organising centres in eukaryotic cells);Aurora B (aka, Aurora 1) functions in the attachment of the mitotic spindle to the centromere;Aurora C (AURKC) works in germ-line cells and little is known about its function.

  • Aurora A Inhibitor I EY1189

    1-Azakenpaullone是一种高度选择性GSK-3β抑制剂,IC50 为18 nM, 其选择性高于CDK1/cyclin B 和 CDK5/p25 100倍。

    More
  • AMG-900 EY1836

    AMG 900是泛Aurora抑制剂,对Aurora A,B和C的IC50分别为5 nM,4 nM和1 nM。

    More
  • Hesperadin EY1547

    Hesperadin是ATP竞争性Aurora B抑制剂,IC50为250 nM。

    More
  • MLN8054 EY1495

    MLN8054是一种有效的,选择性的Aurora A抑制剂,IC50为4 nM,作用于Aurora A比作用于Aurora B选择性高40倍。

    More
  • SNS-314 Mesylate EY1336

    SNS-314是Aurora A,Aurora B和Aurora C抑制剂,IC50分别为9 nM,31 nM和3 nM。

    More
  • Aurora A Inhibitor I EY1189

    1-Azakenpaullone是一种高度选择性GSK-3β抑制剂,IC50 为18 nM, 其选择性高于CDK1/cyclin B 和 CDK5/p25 100倍。

    More
  • AMG-900 EY1836

    AMG 900是泛Aurora抑制剂,对Aurora A,B和C的IC50分别为5 nM,4 nM和1 nM。

    More
  • Hesperadin EY1547

    Hesperadin是ATP竞争性Aurora B抑制剂,IC50为250 nM。

    More
  • MLN8054 EY1495

    MLN8054是一种有效的,选择性的Aurora A抑制剂,IC50为4 nM,作用于Aurora A比作用于Aurora B选择性高40倍。

    More
  • SNS-314 Mesylate EY1336

    SNS-314是Aurora A,Aurora B和Aurora C抑制剂,IC50分别为9 nM,31 nM和3 nM。

    More
  • Current page2, Total Pages4, Total Record17 First Prev 1234 Next Last Goto